415 IL-17C: Checkpoint in innate skin immunology

Promotes Psoriasiform Skin Inflammation Keratinocyte Overexpression of IL-17C

Innate and Cellular Immunology in Parasitic Diseases

1. Professor, Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México. Av. De Los Barrios No. 1 Los Reyes Iztacala, Tlalnepantla, Edo. De México, 54090 MEXICO. 2. Professor, Departments of Pathology and Microbiology. Starling Loving Hall M418. The Ohio State University, Columbus, Ohio, USA 3. Researcher, Instituto de Investigaciones Biomédicas, U...

Signaling through IL-17C/IL-17RE Is Dispensable for Immunity to Systemic, Oral and Cutaneous Candidiasis

Candida albicans is a commensal fungal microbe of the human orogastrointestinal tract and skin. C. albicans causes multiple forms of disease in immunocompromised patients, including oral, vaginal, dermal and disseminated candidiasis. The cytokine IL-17 (IL-17A) and its receptor subunits, IL-17RA and IL-17RC, are required for protection to most forms of candidiasis. The importance of the IL-17R ...

Microenvironment and Immunology IL-17 Enhances Tumor Development in Carcinogen-Induced Skin Cancer

Inflammatory conditions elicited by extrinsic environmental factors promote malignant cell transformation, tumor growth, and metastasis. Although most attention has been focused on innate immune mechanisms of inflammatory carcinogenesis, more recently the role of T cells in cancer promotion has been examined. Although IFN-dependent Th1 responses that promote Stat1 signaling inhibit tumor growth...

Sensing Danger: Innate Immunology for Intrusion Detection

The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so far with little success. However, these previous systems were largely based on immunological theory from the 1970s and 1980s and over the last decade our und...